AI-driven miniprotein therapeutics

Precision drugs for
the most difficult
cancers to treat

SynFold uses generative AI to design miniprotein therapeutics against undruggable oncology targets — starting with triple-negative breast cancer, the most aggressive and treatment-resistant subtype.

28+
Miniprotein candidates in screening
10×
Faster than conventional design
1st
AI-designed TNBC miniprotein platform
Candidate screening — active
SF-001
92
SF-007
88
SF-014
81
SF-019
76
SF-023
71

From target to candidate in weeks, not years

Our dual computational-experimental pipeline combines generative protein design with rapid in vitro validation — purpose-built for oncology targets that have resisted every small molecule approach.

01 — TARGET
Target identification
Structural analysis of TNBC oncology driver nodes. Binding site characterization using AlphaFold3 and cryo-EM data.
AlphaFold3
02 — DESIGN
Generative design
RFdiffusion and ProteinMPNN generate diverse miniprotein scaffolds optimized for target affinity and metabolic stability.
RFdiffusion · ProteinMPNN
03 — SCREEN
Computational screening
BindCraft and MD simulations rank candidates by predicted binding energy, selectivity, and pharmacokinetic profile.
BindCraft · GROMACS
04 — VALIDATE
Experimental validation
3D spheroid toxicity assays, RT-qPCR pathway readouts, and patient-derived models at Hospital de Santa Maria, Lisbon.
3D spheroids · RT-qPCR
Input
Target structure
Generated
~500 scaffolds
Shortlisted
28 candidates
In vitro
Active leads
Timeline
Weeks, not years
Technology stack
AlphaFold3
RFdiffusion
ProteinMPNN
BindCraft
GROMACS
PyMOL
Boltz
3D spheroid models
Patient-derived models

Built by scientists who think like founders

Our team combines world-class expertise in AI protein design, structural biology, oncology, and drug development — operating at the intersection of computation and the clinic.

CT
Catarina Tavares
Founder · AI Miniprotein Design & TNBC Drug Discovery
GIMM · FMUL · ULisboa
DL
Diana Lousa
Computational Drug Design
ITQB · NOVA
VN
Vera Neves
Scientific Advisor · Oncology
GIMM · ULisboa
MC
Miguel Castanho
Scientific Advisor · Principal Investigator
GIMM · FMUL · ULisboa
CL
Cláudio
JV
João
MA
Marco
AR
Anna Reichel
Technology Transfer & IP
GIMM TTO

Ready to explore
a partnership?

We are selectively engaging with investors and strategic partners who share our conviction that AI-designed miniproteins are the next generation of precision oncology therapeutics.

Get in touch View pipeline →